Lauren Endres

Education
- NIEHS Fellow, College of Nanoscale Science and Engineering, SUNY Poly (2009)
- Post Doctoral Fellow, Cutaneous Biology Research Center, Harvard Medical School (2005)
- Ph.D. in Medical Biophysics, University of Toronto (2005)
- M.Sc. in Medical Genetics, University of Toronto (1999)
- B.Sc. in Biology and Biotechnology, York University (1996)
Areas of Research
- Translational responses to oxidative stress
- Oxidative stress in malignant cancer cell progression
- Gene-environment interactions that initiate cancer
- Interrelationships between translation mechanisms and cancer cell signaling
- New cancer therapeutics and prevention strategies
Honors and Awards
- National Research Service Award (NRSA), National Institutes of Environmental Health Sciences, NIH
- Post Doctoral Fellowship Award, Massachusetts General Hospital Fund for Medical Discovery
- Elected Graduate Student Union Representative, Department of Medical Biophysics, University of Toronto
- Natural Sciences and Engineering Research Council (NSERC) Graduate Scholarship
- Ontario Graduate Scholarship
- Hospital for Sick Children’s Research and Training Competition Award
- York University Continuing Student Scholarship
- Affiliate member of the RNA Institute – www.rna.albany.edu
Research Description
The broad goal of my research program is to understand translational defense mechanisms that protect against oxidative-stress, with implications for the prevention of cancer and its progression from a benign to a malignant state. Specifically, I am investigating tRNA methyltransferases that are reactive oxygen species responsive and that show deregulated expression in a number of cancers, including colon, bladder, breast and ovarian. I aim understand the interrelationships between these fascinating enzymes, the modifications they catalyze, and known oncogenic and tumor suppressor signaling pathways.
Selected Publications
- Endres L., Begley U., Clark R., Gu C., Dziergowska A., Małkiewicz A., Melendez J.A., Dedon P.C., Begley TJ. (2015). Alkbh8 Regulates Selenocysteine-Protein Expression to Protect against Reactive Oxygen Species Damage. PLoS One. Jul 6;10(7)
- Endres L., Dedon P.C., Begley T.J. (2015) Codon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responses. RNA Biol. 12(6)
- Begley U., Sosa M.S., Avivar-Valderas A., Patil A., Endres L., Estrada Y., Chan C.T., Su D., Dedon P.C., Aguirre-Ghiso J.A., Begley T.J. (2013). A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α. EMBO Molecular Medecine. 5(3)
- Brown-Endres L., Schoenfeld D., Tian F., Kim H.G., Namba T., Muñoz-Fontela C., Mandinova A., Aaronson S.A., Lee S.W. (2012). Expression of the p53 target CDIP correlates with sensitivity to TNFα-induced apoptosis in cancer cells. Cancer Res.72(9)
- Assaily W., Rubinger D.A., Wheaton K., Lin Y., Ma W., Xuan W., Brown-Endres L., Tsuchihara K., Mak T.W., Benchimol S. (2011). ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress. Mol Cell. 44(3)
- Brown L., Ongusaha PP., Kim HG., Nuti S., Mandinova A., Lee JW., Khosravi-Far R., Aaronson SA., Lee SW. (2007). CDIP, a novel pro-apoptotic gene, regulates TNF alpha-mediated apoptosis in a p53-dependent manner. EMBO J. 26(14)
- Tsuchihara K., Lapin V., Bakal C., Okada H., Brown L., Hirota-Tsuchihara M., Zaugg K., Ho A., Itie-Youten A., Harris-Brandts M., Rottapel R., Richardson CD., Benchimol S., Mak TW. (2005). Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. Cancer Res. 65(15)